| Autor: |
Cong-Shu, Hua, Dong-Chun, Ma, Hai, Chen, Chao-Dong, Zhang, Wen-Sheng, Wang, Xiang, Ding, Jian, Zhao, Feng, Wu |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 49(3) |
| ISSN: |
1672-173X |
| Popis: |
To investigate the relationship between expression of tumor suppressor geneThe expression of p16 protein in 76 cases of NSCLC tissues and normal tissue adjacent to carcinoma were detect by immunohistochemical SP method and the differences of p16 protein expression were analyzed.32 cases (42.11%) of p16 protein expression was positive,significantly lower than that of the normal tissue adjacent to carcinoma (positive expression in 59 cases,77.63%) in 76 cases of NSCLC tissues; There were statistically significant differences (The low expression of p16 in NSCLC tissues with squamous cell carcinomas,low differentiation,lymph node metastasis and phase Ⅲ-Ⅳ,which may prompt the deactivation and cause further progression of NSCLC,5-Aza-CdR could induce the expression of p16 protein and non-methylated products in A549 cells. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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