Humanisation of monoclonal antibodies for therapy

Autor:	S D, Gorman, M R, Clark
Rok vydání:	1990
Předmět:	Mice Species Specificity Animals Antibodies Monoclonal Humans Mice Transgenic Immunoglobulin Allotypes Protein Engineering Recombinant Proteins
Zdroj:	Seminars in immunology. 2(6)
ISSN:	1044-5323
Popis:	Monoclonal antibodies are playing an increasing role in many experimental therapies. A major limitation of their use is that they are recognised by the patient as being of foreign origin and an antiglobulin response is provoked. Recombinant DNA technology offers the ability to convert these rodent antibodies into a more human form. Different degrees of humanisation can be achieved ranging from chimeric antibodies with a combination of human constant regions with rodent variable regions to fully reshaped antibodies where the variable regions are also humanised. Encouraging preliminary results have been obtained and it seems likely that these will dictate the use of humanisation as a required procedure in the therapeutic use of monoclonal antibodies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::90b0677e7202575cf0ba57375d2962fe https://pubmed.ncbi.nlm.nih.gov/2104282 Zobrazit plný text záznamu