| Autor: |
Zheng-Mao, Li, Xiu-Xiu, Liu, Chen, Li, Zhao-Cong, Wei, Yi, Shi, Heng-Yi, Song, Xiang, Chen, Yu, Zhang, Jia-Wei, Li, Rui-Fang, Zhu, Ben-Hui, Hu, Wei-Feng, Ye, Da, Huo, Guo-Jun, Jiang, Takuya, Sasaki, Li, Zhang, Feng, Han, Ying-Mei, Lu |
| Rok vydání: |
2021 |
| Zdroj: |
MedComm. 3(3) |
| ISSN: |
2688-2663 |
| Popis: |
Accumulating evidence indicates that epilepsy has a higher risk of inducing memory impairment and dementia. However, the underlying onset mechanism remains unclear. Here, we found that mice with spontaneous epilepsy induced by endothelial CDK5 deficiency exhibited hippocampal-dependent memory impairment at 6 months of age, but not at 2 months of age. Moreover, the persistent epileptic seizures induce aberrant changes in phosphorylation of CaMKII protein in the hippocampus of spontaneous epileptic mice. Using genome-wide RNA sequencing and intergenic interaction analysis of STRING, we found that in addition to epilepsy-related genes, there are changes in synaptic organization pathway node genes, such as |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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