Cessation of long-term nicotine gum use--a prospective, randomized trial

Autor:	R D, Hurt, K P, Offord, G G, Lauger, Z, Marusić, K O, Fagerström, P L, Enright, P D, Scanlon
Rok vydání:	1995
Předmět:	Adult Male Motivation Nicotine Dose-Response Relationship Drug Substance-Related Disorders Middle Aged Long-Term Care Drug Administration Schedule Chewing Gum Risk Factors Humans Female Smoking Cessation Follow-Up Studies
Zdroj:	Addiction (Abingdon, England). 90(3)
ISSN:	0965-2140
Popis:	Nicotine gum is an important adjunct for smoking cessation for many smokers, and long-term use of nicotine gum will occur in a small percentage of patients. To date, no method of cessation in long-term users has been studied in a randomized trial. We enrolled 26 subjects at the Mayo Clinic site of the Lung Health Study who had used nicotine gum for more than 6 months to participate in a trial where subjects were randomly assigned to: (1) abrupt cessation, (2) taper with placebo gum, or (3) taper with active gum. At the end of the 6-week trial, the percentage of subjects abstinent from gum use and not smoking was not different among the three groups: 66.7% for the abrupt cessation group, 71.4% for the taper with placebo gum group and 60% for the taper with active gum group. One subject in the taper with placebo gum group relapsed to smoking during the trial but was abstinent from smoking again at long-term follow-up. Long-term follow-up (median 284 days) showed 65% of subjects were abstinent from all nicotine products. Motivated subjects can stop long-term nicotine gum use without relapse to gum use or smoking by either abrupt cessation or brief tapering.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::908ef82bcc6b0f59f75c4fefe6b692c4 https://pubmed.ncbi.nlm.nih.gov/8616471 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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