Dose-proportional absorption of etretinate after doses of 25, 50, 75, and 100 mg

Autor:	R J, Wills, L C, Rodriguez, A H, Lin, C, Puccini, W A, Colburn
Rok vydání:	1987
Předmět:	Adult Male Dose-Response Relationship Drug Etretinate Humans
Zdroj:	Pharmaceutical research. 4(5)
ISSN:	0724-8741
Popis:	Twelve healthy male subjects received single oral doses of etretinate, ranging from 25 to 100 mg (1 to 4 x 25-mg capsules) in an open-label, four-way randomized crossover design. Plasma concentrations of etretinate and two active metabolites were determined by a specific high-performance liquid chromatographic (HPLC) method. Analysis of variance and orthogonal contrasts were used to assess dose proportionality. Mean (+/- %CV) maximum concentrations after 25- to 100-mg doses were 133 (50), 195 (33), 261 (53), and 446 (65) ng/ml, whereas AUC0-12 values were 581 (46), 1090 (39), 1500 (52), and 2440 (63) ng.hr/ml, respectively. The test for proportionality indicated that Cmax and AUC0-12 increased proportionally with an increase in dose (P greater than 0.05).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::905c2599b6845af8fa3cd5ff9cb2e8c8 https://pubmed.ncbi.nlm.nih.gov/3508553 Zobrazit plný text záznamu Full text from SpringerLink