| Autor: |
Abdelbaset, Buhmeida, Raija, Ristamäki, Hanan, Lamlum, Riyad, Bendardaf, Suvi, Heikkilä, Yrjö, Collan, Kari, Syrjänen, Seppo, Pyrhönen |
| Rok vydání: |
2005 |
| Předmět: |
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| Zdroj: |
Anticancer research. 25(4) |
| ISSN: |
0250-7005 |
| Popis: |
The prognostic value of morphometric nuclear features in Dukes' Stages B/C and D colorectal cancer (CRC) was assessed.Primary tumours from 86 CRC patients were analysed, using an image overlay drawing system (Prodit Morphometry Program), for the following nuclear features: area, perimeter, diameter, form factor, roundness.The median nuclear area (NA) was 104.6 microm2 (range 57.2 - 237.2 microm2). The NA was larger in patients with lymph node metastasis (p0.02). Altogether, 43% of the patients showed clinical response to irinotecan-based chemotherapy. All six patients with complete response (CR) had a NA above the median (p0.03). The disease-specific survival of the patients with a NA above the median was significantly better than in patients with smaller NA (p0.02).Using the median NA as the cut-off value seems to effectively discriminate patients who are likely to respond to irinotecan-based chemotherapy (with improved prognosis) from those who are non-responsive and develop progressive disease. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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