| Autor: |
J C, Duche, J, Barre, P, Guinot, J, Duchier, A, Cournot, J P, Tillement |
| Rok vydání: |
1989 |
| Předmět: |
|
| Zdroj: |
International journal of clinical pharmacology research. 9(3) |
| ISSN: |
0251-1649 |
| Popis: |
Twenty-four healthy volunteers were divided in three groups who were randomly assigned different treatments for 13 days: group I received 400 mg/day of a defined Ginkgo biloba extract (GBE), group II 300 mg/day of phenytoin and group III a placebo. The elimination half-life of antipyrine was measured with a high performance liquid chromatographic technique initially and on the last day of the administration of the treatments. The results show that the half-life of antipyrine was not affected by GBE and placebo treatments, whereas it was significantly decreased (p less than 0.05) frm 12.2 to 6.8 h after phenytoin control treatment. This study demonstrates that GBE has no effect on the hepatic microsomal drug oxidation system. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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