Effect of alpha-tocopherol supplementation on renal oxidative stress and Na+/K+ -adenosine triphosphatase in ethanol treated Wistar rats

Autor: Maneesh, Mailankot, H, Jayalekshmi, Amit, Chakrabarti, Neha, Alang, D M, Vasudevan
Rok vydání: 2009
Předmět:
Zdroj: Indian journal of experimental biology. 47(7)
ISSN: 0019-5189
Popis: Ethanol intoxication resulted in high extent of lipid peroxidation, and reduction in antioxidant defenses (decreased GSH, GSH/GSSG ratio, and catalase, SOD and GPx activities) and (Na+/K+)-ATPase activity in kidney. Alpha-tocopherol treatment effectively protected kidney from ethanol induced oxidative challenge and improved renal (Na+/K+)-ATPase activity. Ethanol induced oxidative stress in the kidney and decreased (Na+/K+)-ATPase activity could be reversed by treatment with ascorbic acid.
Databáze: OpenAIRE