[Study of the mechanism of mutagenesis directed by phosphotriester analogs of oligonucleotides. The role of repair in mutagenesis]

Autor:	V A, Petrenko, G A, Kuz'micheva, S I, Tat'kov, I I, Krasnoborov, P I, Pozdniakov, A A, Il'ichev, I A, Baturina, V V, Khomov
Rok vydání:	1990
Předmět:	DNA Bacterial Organophosphorus Compounds Base Sequence DNA Repair Molecular Sequence Data Mutation Escherichia coli Oligonucleotides Transformation Bacterial Organophosphates Mutagens Plasmids
Zdroj:	Molekuliarnaia biologiia. 24(2)
ISSN:	0026-8984
Popis:	The mutation system has been suggested in an effort to test insertion and deletion mutants by changing the Lac-phenotype of bacterial colonies transformed by mutant DNA. This system also makes possible to determine heterozygotes and homozygotes among the mutants. The yield of mutants in shown to depend on the structure of the DNA heteroduplex region. The yield of deletion mutants is greater than that of insertion mutants. Heterozygotes prevail in mutant colonies (greater than 90%).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::902308566cbec7fc72239fd5ebf1911a https://pubmed.ncbi.nlm.nih.gov/2194116 Zobrazit plný text záznamu