| Autor: |
Miguel Angel, Gorriti, Belén, Ferrer, Ignacio, del Arco, Francisco Javier, Bermúdez-Silva, Yolanda, de Diego, Emilio, Fernandez-Espejo, Miguel, Navarro, Fernando, Rodríguez de Fonseca |
| Rok vydání: |
2004 |
| Předmět: |
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| Zdroj: |
Pharmacology, biochemistry, and behavior. 81(1) |
| ISSN: |
0091-3057 |
| Popis: |
The endogenous cannabinoid system works as a feedback signal controlling dopamine-induced facilitation of motor behaviors. The present study explored whether a single acute stimulation of CB1 cannabinoid receptors with (-)-Delta9-tetrahydrocannabinol (THC, 5 mg kg(-1) i.p.) results in modifications in the sensitivity to the acute behavioral effects of the dopamine D2/D3 receptor agonist quinpirole (0.025, 0.25 and 1 mg kg(-1), s.c.) 24 h after THC administration. Cannabinoid pretreatment increased the sensitivity to quinpirole-induced hyperlocomotion 24 h after its administration. The data indicated that THC induced a desensitization of cannabinoid receptors, as revealed by a reduction in CB1 receptor-agonist induced GTP-gamma-S incorporation in striatal membranes. These results might be relevant for understanding the effect of cannabinoid exposure in dopamine-related neuropsychiatric disorders. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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