Increased mean aliphatic lipid chain length in left ventricular hypertrophy secondary to arterial hypertension
| Autor: | Evaristi, Maria Francesca, Caubère, Céline, Harmancey, Romain, Desmoulin, Franck, Peacock, William Frank, Berry, Matthieu, Turkieh, Annie, Barutaut, Manon, Galinier, Michel, Dambrin, Camille, Polidori, Carlo, Miceli, Cristina, Chamontin, Bernard, Koukoui, François, Roncalli, Jerôme, Massabuau, Pierre, Smih, Fatima, Rouet, Philippe |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | About 77.9 million (1 in 4) American adults have high blood pressure. High blood pressure is the primary cause of left ventricular hypertrophy (LVH), which represents a strong predictor of future heart failure and cardiovascular mortality. Previous studies have shown an altered metabolic profile in hypertensive patients with LVH. The goal of this study was to identify blood metabolomic LVH biomarkers by 1H NMR to provide novel diagnostic tools for rapid LVH detection in populations of hypertensive individuals. This cross-sectional study included 48 hypertensive patients with LVH matched with 48 hypertensive patients with normal LV size, and 24 healthy controls. Two-dimensional targeted M-mode echocardiography was performed to measure left ventricular mass index. Partial least squares discriminant analysis was used for the multivariate analysis of the 1H NMR spectral data. From the 1H NMR-based metabolomic profiling, signals coming from methylene (–CH2–) and methyl (–CH3) moieties of aliphatic chains from plasma lipids were identified as discriminant variables. The –CH2–/–CH3 ratio, an indicator of the mean length of the aliphatic lipid chains, was significantly higher (P |
| Databáze: | OpenAIRE |
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