| Autor: |
P Patrizia, Mangione, Guglielmo, Verona, Alessandra, Corazza, Julien, Marcoux, Diana, Canetti, Sofia, Giorgetti, Sara, Raimondi, Monica, Stoppini, Marilena, Esposito, Annalisa, Relini, Claudio, Canale, Maurizia, Valli, Loredana, Marchese, Giulia, Faravelli, Laura, Obici, Philip N, Hawkins, Graham W, Taylor, Julian D, Gillmore, Mark B, Pepys, Vittorio, Bellotti |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
The Journal of biological chemistry. 293(37) |
| ISSN: |
1083-351X |
| Popis: |
Systemic amyloidosis is a usually fatal disease caused by extracellular accumulation of abnormal protein fibers, amyloid fibrils, derived by misfolding and aggregation of soluble globular plasma protein precursors. Both WT and genetic variants of the normal plasma protein transthyretin (TTR) form amyloid, but neither the misfolding leading to fibrillogenesis nor the anatomical localization of TTR amyloid deposition are understood. We have previously shown that, under physiological conditions, trypsin cleaves human TTR in a mechano-enzymatic mechanism that generates abundant amyloid fibrils |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
