| Autor: |
Michael M, Meguid, Eduardo J B, Ramos, Susumu, Suzuki, Yuan, Xu, Zachariah M, George, Undurti N, Das, Karen, Hughes, Robert, Quinn, Chung, Chen, William, Marx, Paul R G, Cunningham |
| Rok vydání: |
2004 |
| Předmět: |
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| Zdroj: |
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 8(5) |
| ISSN: |
1091-255X |
| Popis: |
Obesity affects 30% of the United States population and its detrimental effects are obesity-related metabolic diseases. For patients refractory to conventional weight loss therapy, gastric bypass surgery is one of the proven methods for inducing a sustained weight loss and reversing the metabolic sequelae of obesity. To understand the mechanisms of weight loss and the amelioration of related metabolic comorbid conditions, a reproducible animal model is needed. We report our developmental experience with rat models of sequential Roux-en-Y gastric bypass after reproducing the diet-induced obesity that characterizes the hallmarks of human obesity. Four experiments were performed to induce weight reduction through successive modifications: In Experiment 1 a 20% stapled gastric pouch with a 16 cm biliary-pancreatic limb and a 10 cm alimentary limb accomplished sufficient weight loss within 10 days to ameliorate metabolic changes associated with obesity, but the occurrence of gastrogastric fistulas prevented sustained weight loss; in Experiment 2 the model was improved by dividing the stomach to avoid gastrogastric fistula, but again sustained weight loss was not achieved; in Experiment 3 the biliary-pancreatic limb was lengthened from 16 to 30 cm, reducing the common channel to approximately 18 cm. Sustained weight loss was achieved for 28 days. In Experiment 4 the model in Experiment 3 was modified by dividing the stomach between two rows of staples. Sustained weight loss was observed for 67 days. We developed a reproducible rat model of Roux-en-Y gastric bypass. The existence of this model opens a new field of research in which to study the metabolic sequelae of obesity and the mechanisms of weight loss. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full text from SpringerLink