N-Acyl amines of docosahexaenoic acid and other n-3 polyunsatured fatty acids - from fishy endocannabinoids to potential leads
| Autor: | Jocelijn, Meijerink, Michiel, Balvers, Renger, Witkamp |
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| Rok vydání: | 2012 |
| Předmět: |
Cannabinoid Receptor Agonists
Themed Section: Cannabinoids 2012 Part Two Docosahexaenoic Acids Polyunsaturated Alkamides Acylation Dopamine Anti-Inflammatory Agents Non-Steroidal Fishes alpha-Linolenic Acid Drug Delivery Systems Fish Oils Neuroprotective Agents Eicosapentaenoic Acid Seafood Dietary Supplements Fatty Acids Omega-3 Animals Humans lipids (amino acids peptides and proteins) Ethanolamine Receptors Cannabinoid Endocannabinoids |
| Zdroj: | British journal of pharmacology. 169(4) |
| ISSN: | 1476-5381 |
| Popis: | N–3 long-chain polyunsaturated fatty acids (n–3 LC-PUFAs), in particular α-linolenic acid (18:3n-3), eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) are receiving much attention because of their presumed beneficial health effects. To explain these, a variety of mechanisms have been proposed, but their interactions with the endocannabinoid system have received relatively little attention so far. However, it has already been shown some time ago that consumption of n–3 LC-PUFAs not only affects the synthesis of prototypic endocannabinoids like anandamide but also stimulates the formation of specific n–3 LC-PUFA-derived conjugates with ethanolamine, dopamine, serotonin or other amines. Some of these fatty amides show overlapping biological activities with those of typical endocannabinoids, whereas others possess distinct and sometimes largely unknown receptor affinities and other properties. The ethanolamine and dopamine conjugates of DHA have been the most investigated thus far. These mediators may provide promising new leads to the field of inflammatory and neurological disorders and for other pharmacological applications, including their use as carrier molecules for neurotransmitters to target the brain. Furthermore, combinations of n–3 LC-PUFA-derived fatty acid amides, their precursors and FAAH inhibitors offer possibilities to optimise their effects in health and disease. |
| Databáze: | OpenAIRE |
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