| Autor: |
A A, Venediktova, O V, Falameeva, N G, Kolosova, M A, Sadovoĭ, T A, Korolenko |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Biomeditsinskaia khimiia. 56(2) |
| ISSN: |
2310-6972 |
| Popis: |
The comparative study of activity of cysteine protease cathepsin K and matrix metalloproteases (MMPs) in bone tissue of accelerated senescent OXYS rats with early ageing comparatively to Wistar rats of the same age was performed. Early development osteoporosis is a typical feature of OXYS rats. In bone tissue of 3 month old OXYS rats, before appearance of osteoporosis manifestation cathepsin K activity was higher, whereas MMPs activity was lower than in Wistar rats. In Wistar rats (3 and 14 months old) cathepsin K activity of spine was shown to increase, and MMPs activity to decrease. In OXYS rats age-related change of cathepsin K and MMPs activity in bone tissue had the opposite direction. As a result of this there were no differences between Wistar and OXYS rats 14 months old despite the marked osteoporosis in OXYS rats as revealed our early researches. Serum Q2-macroglobulin activity was higher in 14 months old OXYS rats. The role of activation of cathepsin K in bone resorption in the development of osteoporosis in early ageing OXYS rats is discussed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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