| Autor: |
Yukie, Omori, Sotaro, Enatsu |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Gan to kagaku ryoho. Cancerchemotherapy. 45(11) |
| ISSN: |
0385-0684 |
| Popis: |
Pemetrexed(Alimta®)is a multi-targeted antifolate that shows antitumor effects by inhibiting enzymes in the folate metabolic pathway essential for cell replication. Pemetrexed is a standard treatment for Japanese patients with nonsquamous, non-small-cell lung cancer. In this review, we summarize the evidence of clinical studies for the efficacy and safety of pemetrexed in the treatment of nonsquamous non-small-cell lung cancer as first-line chemotherapy and continuation maintenance therapy. In addition, we describe future prospects for pemetrexed in combination with a recent approved PD-1 path- way inhibitor. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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