Propionibacterium acnes-associated Sarcoidosis Possibly Initially Triggered by Interferon-alpha Therapy

Autor:	Sawahata, Michiru, Fujiki, Yasumaro, Nakano, Naomi, Ohtsuki, Mamitaro, Yamaguchi, Tetsuo, Uchida, Keisuke, Eishi, Yoshinobu, Suzuki, Takuji, Hagiwara, Koichi, Bando, Masashi
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Sarcoidosis Pulmonary Sarcoidosis Ribavirin drug-induced sarcoidosis-like reaction bilateral hilar and mediastinal lymphadenopathy Humans Interferon-alpha Female Case Report Propionibacterium acnes interferon Neoplasm Recurrence Local Middle Aged
Zdroj:	Internal Medicine
ISSN:	1349-7235 0918-2918
Popis:	A 46-year-old woman with uveitis was referred to our respiratory diseases department in July 2018. Her medical history included transient bilateral hilar mediastinal lymphadenopathy (BHL) and multiple pulmonary nodules in May 2013 during pegylated interferon-alpha and ribavirin treatment for chronic hepatitis C infection. Five years post-treatment, chest X-ray revealed BHL and nodular recurrence. A biopsy of the subcutaneous buttock nodules revealed scattered non-caseating epithelioid granulomas with positive PAB immunohistochemical staining. This seem to be the first report of Propionibacterium acnes-associated sarcoidosis possibly initially triggered by interferon-alpha therapy. Understanding the mechanisms underlying interferon-triggered P. acnes-associated sarcoidosis may clarify the sarcoidosis immunopathogenesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::8f1da3fe29e4092a89900c4e4108dbc7 http://europepmc.org/articles/PMC7990622 Zobrazit plný text záznamu