[Protein E 98-113 sequence is a fusion site of tick-borne encephalitis virus with cellular membrane]

Autor:	T D, Volkova, O M, Vol'pina, V T, Ivanov, V V, Vargin, M F, Vorovich, A V, Timofeev, B F, Semenov, N A, Tsekhanovskaia, E K, Pressman
Rok vydání:	1998
Předmět:	Dose-Response Relationship Drug Macrophages Cell Membrane Molecular Sequence Data Antibodies Monoclonal In Vitro Techniques Peptide Fragments Encephalitis Viruses Tick-Borne Mice Viral Envelope Proteins Macrophages Peritoneal Animals Amino Acid Sequence Antigens Viral Viral Fusion Proteins Spleen
Zdroj:	Bioorganicheskaia khimiia. 24(9)
ISSN:	0132-3423
Popis:	The synthetic peptide with the conservative 98-113 sequence of protein E of tick-borne encephalitis virus was studied in order to elucidate its role in the functioning of flaviviruses. The peptide was shown to inhibit the in vitro infection of macrophages with the virus. An antibody that specifically binds this peptide was found among the set of monoclonal antibodies produced against protein E. This antibody was found to prevent penetration of the virus into liposomes. A correlation was found between our results and data on the spatial structure of protein E and its interspecies homology. The protein E 98-113 sequence of the tick-borne encephalitis virus was found to be the fusion site of the viral envelope with a cellular membrane.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::8f1d40b82ce75c62390cafcaac12cb00 https://pubmed.ncbi.nlm.nih.gov/9813732 Zobrazit plný text záznamu