Extracranial giant cell arteritis: A narrative review
| Autor: | K D F, Lensen, A E, Voskuyl, E F I, Comans, C J, van der Laken, Y M, Smulders |
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| Rok vydání: | 2016 |
| Předmět: |
Carotid Artery Diseases
Aortitis Aortic Arch Syndromes Computed Tomography Angiography Biopsy Giant Cell Arteritis Subclavian Artery Prognosis Iliac Artery Aortic Aneurysm Mesenteric Arteries Temporal Arteries Femoral Artery Aortic Dissection Renal Artery Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography Axillary Artery Humans Radiopharmaceuticals Glucocorticoids Vascular Surgical Procedures Immunosuppressive Agents Magnetic Resonance Angiography |
| Zdroj: | The Netherlands journal of medicine. 74(5) |
| ISSN: | 1872-9061 |
| Popis: | A systematic literature search was performed to summarise current knowledge on extracranial giant cell arteritis (GCA), i.e. large-artery involvement in patients with or without clinically apparent temporal arteritis (cranial GCA). Extracranial GCA is increasingly recognised, both in patients with cranial GCA and with solitary extracranial GCA, due to increased awareness among physicians and development of modern imaging modalities. The literature on the pathogenesis and histopathology of extracranial GCA is scarce. It is considered to be similar to cranial GCA. Patients with solitary extracranial GCA often present with non-specific signs and symptoms, although vascular manifestations, mostly secondary to stenosis, may occur. Due to the non-specific clinical presentation and low sensitivity of temporal artery biopsies, extracranial GCA is usually diagnosed by imaging. 18F-FDG-PET, MRI, CT angiography and ultrasound are used for this purpose. At present, the optimal diagnostic strategy is undetermined. The choice for a particular modality can be guided by the clinical scenario that raises suspicion of extracranial GCA, in addition to local availability and expertise. Extracranial complications in GCA consist of aortic aneurysm or dissection (mainly the ascending aorta), aortic arch syndrome, arm claudication and posterior stroke (although this is technically a cranial complication, it often results from stenosis of the vertebrobasilar arteries). Mortality is generally not increased in patients with GCA. Treatment of patients with solitary extracranial and those with extracranial and cranial GCA has been debated in the recent literature. In general, the same strategy is applied as in patients with temporal arteritis, although criteria regarding who to treat are unclear. Surgical procedures may be indicated, in which case optimal medical treatment prior to surgery is important. |
| Databáze: | OpenAIRE |
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