CRISPR-dCas9 Mediated Cytosine Deaminase Base Editing in

Autor:	Sili, Yu, Marcus A, Price, Yu, Wang, Yang, Liu, Yanmei, Guo, Xiaomeng, Ni, Susan J, Rosser, Changhao, Bi, Meng, Wang
Rok vydání:	2020
Předmět:	Gene Editing Streptococcus pyogenes Cytosine Deaminase Bacterial Proteins Genetic Loci CRISPR-Associated Protein 9 Cytidine Deaminase Point Mutation Clustered Regularly Interspaced Short Palindromic Repeats DNA Breaks Double-Stranded CRISPR-Cas Systems Genome Bacterial Bacillus subtilis Plasmids
Zdroj:	ACS synthetic biology. 9(7)
ISSN:	2161-5063
Popis:	Base editing technology based on clustered regularly interspaced short palindromic repeats/associated protein 9 (CRISPR/Cas9) is a recent addition to the family of CRISPR technologies. Compared with the traditional CRISPR/Cas9 technology, it does not rely on DNA double strand break and homologous recombination, and can realize gene inactivation and point mutation more quickly and simply. Herein, we first developed a base editing method for genome editing in
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::8ed6dc5b0058b4497e8bfb9af07e34bd https://pubmed.ncbi.nlm.nih.gov/32551562 Zobrazit plný text záznamu