| Autor: |
Hong, Zhao, Gui-qiang, Wang, Zhong-hou, Han, Min, Yu, Yu-hua, Wang, Xie-wen, Sun, Yan-yan, Yu, Qin-huan, Wang, Chong-wen, Si, Geng-shan, Tian, Xiang-yun, Han |
| Rok vydání: |
2005 |
| Předmět: |
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| Zdroj: |
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology. 19(1) |
| ISSN: |
1003-9279 |
| Popis: |
To evaluate the correlation between the efficacy of interferon-alpha-2a and the kinetics of viral load in serum.The authors conducted a trial including 58 patients with chronic hepatitis B. Patients were treated with interferon-alpha-2a three times a week for 6 months. Viral kinetics were assessed by serial quantitive measurements of HBV-DNA.A significant decline of serum HBV-DNA was seen after interferon-alpha-2a administration for 1 month, the decreases were (2.50 +/- 0.44) log10, (1.62 +/- 1.12) log10 and (1.05 +/- 1.35) log10 for complete responders, partial responders and no-responders, respectively. After 1 month of treatment, HBV-DNA level was (3.99 +/- 0.91) log10 for complete responders versus (5.63 +/- 1.31) log10 for partial responders, and (6.69 +/- 1.42) log10 for no-responders (P0.05). Multivariate analysis suggested that undetectable serum HBV-DNA after 1 month of interferon-alpha-2a treatment was associated with better efficacy; higher baseline ALT or/and no family history were also correlated with better treatment outcomes.Kinetics of HBV-DNA level under interferon-alpha-2a treatment are highly predictive of therapeutic response. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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