Dual functional nanoparticles efficiently across the blood-brain barrier to combat glioblastoma
| Autor: | Zheng, Jin, Lianhua, Piao, Guangchao, Sun, Chuanxiang, Lv, Yi, Jing, Rihua, Jin |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Dendrimers Mice Inbred BALB C Brain Neoplasms Antibodies Monoclonal Mice Nude Mice Drug Delivery Systems Blood-Brain Barrier Cell Line Tumor Tumor Microenvironment Animals Humans Nanoparticles RNA Long Noncoding Phosphatidylinositol 3-Kinase RNA Small Interfering Glioblastoma NK Cell Lectin-Like Receptor Subfamily C Immune Checkpoint Inhibitors |
| Zdroj: | Journal of drug targeting. 29(3) |
| ISSN: | 1029-2330 |
| Popis: | The blood-brain barrier (BBB) and complex tumour immunosuppressive micro-environment posed austere challenges for combatting brain tumours such as the glioblastoma. In this study, we have developed a novel dual functional dendrimer drug delivery system (DDS) by the PAMAM and loaded with siLSINCT5 (NP- siRNA) for efficiently across the BBB to inhibit glioblastoma. To achieve the goal of BBB crossing, on the surface of NP-siRNA was decorated with the cell penetrating peptides tLyp-1 (tLypNP-siRNA). Moreover, to overcome the immunosuppressive microenvironment within the glioblastoma (GBM) tissues, a checkpoint inhibitor named as anti-NKG2A monoclonal antibody (aNKG2A), which was able of promoting anti-tumour immunity by unleashing both T and NK Cells, was further conjugated on the surface of siLSINCT5-loaded nanoparticles |
| Databáze: | OpenAIRE |
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