Chronic migraine caused a higher rate of tendency to cannabinoid agonist compared to morphine
| Autor: | Mansoori, Mojdeh, Zarei, Mohammad Reza, Chamani, Goli, Nazeri, Masoud, Mohammadi, Fatemeh, Alavi, Samane Sadat, Shabani, Mohammad |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Acta Bio Medica : Atenei Parmensis |
| ISSN: | 2531-6745 0392-4203 |
| Popis: | Opioid and cannabinoid systems have considerable roles in the modulation of chronic pain as well as regulation reward circuit and addiction responses. This study investigated the effect of nitroglycerin (NTG)-induced migraine attack on the acquisition of morphine and cannabinoid-induced conditioned place preference (CPP) in male rats. Adult male rats (230-250 gr) were used. Experimental groups were included (n=10): control, opioid receptor agonist morphine (10 mg/kg), WIN55,212-2 (1 mg/kg) as a cannabinoid receptor agonist, NTG + morphine (10 mg/kg) and NTG + WIN55,212-2 (1 mg/kg). Nitroglycerin (10 mg/kg) was used to induce migraine attacks every other day for 9 days. After migraine induction, conditioning performance was assessed by CPP test. During conditioning days, morphine and WIN55,212-2 were injected subcutaneously and intraperitoneally, respectively. Anxiety and locomotor activity were evaluated using open field test (OFT). According to data, conditioning score for morphine-treated rats was significantly decreased following NTG-induced migraine (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|