| Autor: |
C M, Davis, T M, McLaughlin, T J, Watson, R H, Buckley, S E, Schiff, L P, Hale, B F, Haynes, M L, Markert |
| Rok vydání: |
1997 |
| Předmět: |
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| Zdroj: |
Journal of clinical immunology. 17(2) |
| ISSN: |
0271-9142 |
| Popis: |
Complete DiGeorge syndrome is an immunodeficiency disease characterized by thymic aplasia and the absence of functioning peripheral T cells. A patient with this syndrome was transplanted with cultured postnatal human thymic tissue. Within 5 weeks of transplantation, flow cytometry, T cell receptor V beta sequence analysis, and cell function studies showed the presence of oligoclonal populations of nonfunctional clonally expanded peripheral T cells that were derived from pretransplantation T cells present in the skin. However, at 3 months posttransplantation, a biopsy of the transplanted thymus showed normal intrathymic T cell maturation of host T cells with normal TCR V beta expression on thymocytes. By 9 months postransplantation, peripheral T cell function was restored and the TCR V beta repertoire became polyclonal, coincident with the appearance of normal T cell function. These data suggest that the transplanted thymus was responsible for the establishment of a new T cell repertoire via thymopoiesis in the chimeric thymic graft. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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