[Characteristics of the mutagenic and toxic effects of ethylene imine and its oligomers. Comparative study in the automated SOS-chromotest system and in standard bacterial test systems]

Autor:	T B, Tanirbergenov, S V, Vasil'eva, R G, Kostianovskiĭ, I A, Rappoport, T, Huttunen
Rok vydání:	1988
Předmět:	Salmonella typhimurium Structure-Activity Relationship DNA Repair Azirines Mutagenicity Tests Aziridines Escherichia coli SOS Response Genetics Mutagens
Zdroj:	Genetika. 24(4)
ISSN:	0016-6758
Popis:	Raising total positive charge of a chemical mutagen does increase its local concentration in the area of biological target-DNA, and, as a consequence, causes increase in the rate of interaction of a mutagen with the target. Experimental evidence of this idea has been obtained in three test systems: the Ames test, Trp+ reversions in Escherichia coli WP2 and in the automated "SOS-chromotest" system with E. coli PQ 37 ("Labsystems", Finland).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::8e49c7e1e0edce52656762fe7480b430 https://pubmed.ncbi.nlm.nih.gov/3294106 Zobrazit plný text záznamu