[Characteristics of the mutagenic and toxic effects of ethylene imine and its oligomers. Comparative study in the automated SOS-chromotest system and in standard bacterial test systems]
Autor: | T B, Tanirbergenov, S V, Vasil'eva, R G, Kostianovskiĭ, I A, Rappoport, T, Huttunen |
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Rok vydání: | 1988 |
Předmět: | |
Zdroj: | Genetika. 24(4) |
ISSN: | 0016-6758 |
Popis: | Raising total positive charge of a chemical mutagen does increase its local concentration in the area of biological target-DNA, and, as a consequence, causes increase in the rate of interaction of a mutagen with the target. Experimental evidence of this idea has been obtained in three test systems: the Ames test, Trp+ reversions in Escherichia coli WP2 and in the automated "SOS-chromotest" system with E. coli PQ 37 ("Labsystems", Finland). |
Databáze: | OpenAIRE |
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