| Autor: |
Yitong, Zhang, Yanyun, Ma, Weihong, Xu, Wenshuai, Li, Pei, Min, Jigang, Qiu, Min, Li, Feng, Tang, Mingqing, Zhang, Dongqin, Yang, Jun, Zhang |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 22(2) |
| ISSN: |
1107-0625 |
| Popis: |
Common single-nucleotide polymorphisms (SNPs) in microRNAs (miRs) have been shown to be associated with susceptibility to several types of human cancer. However, the association of miR-933 rs79402775 with gastric cancer (GC) has not been explored.The association between rs79402775 in miR- 933 and the risk of GC was explored in Chinese population based on MassARRAY technology. A total 374 GC patients and 999 cancer-free controls were enrolled in this study.Compared with the wild-type GG, GA genotype was associated with a significantly decreased risk of GC (OR=0.542, 95% CI=0.299-0.983, p=0.044) in female subjects. Moreover, the variant was also associated with the expression of alpha fetoprotein (AFP) and carcinoembryonic antigen (CEA).miR-933(rs79402775) may contribute to decreased susceptibility to GC and this SNP could be developed as a biomarker for GC prognosis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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