| Autor: |
Rui-Jie, Li, Chao-Yan, Wu, Hao-Liang, Ke, Xiu-Ping, Wang, Ying-Wen, Zhang |
| Rok vydání: |
2022 |
| Zdroj: |
Iranian journal of basic medical sciences. 26(1) |
| ISSN: |
2008-3866 |
| Popis: |
We aimed to investigate the preventative effect of Qing Fei Hua Xian Decoction (QFHXD) against pulmonary fibrosis (PF) and its potential mechanisms.Bleomycin (BLM)-induced rats were respectively treated with 413.3, 826.6, and 1239.9 mg/kg of QFHXD and prednisone for 28 days. The lung tissues of rats were collected on day 28 for histological and western blotting analysis.QFHXD significantly reduced alveolus inflammation, collagen accumulation, and fibrosis deposition in BLM-induced PF rats (QFHXD suppressed inflammatory infiltration and PF brought on by BLM in lung tissues through reducing oxidative stress by maintaining the equilibrium of ACE-AngII-AT1R and ACE2-Ang-(1-7) -Mas axes. This study may provide a novel clinical therapy option for PF. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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