A specific stimulator of granulocyte colony-stimulating factor accelerates recovery from cyclophosphamide-induced neutropenia in the mouse
| Autor: | J S, Fine, X Y, Cai, L, Justice, C P, Gommoll, L D, Hamilton, T A, Waters, S K, Narula, L A, Bober, M J, Grace |
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| Rok vydání: | 1997 |
| Předmět: |
Mice
Inbred BALB C Neutropenia Transcription Genetic Neutrophils Hematopoietic Stem Cells Monocytes Recombinant Proteins Hematopoiesis Kinetics Mice Bone Marrow Granulocyte Colony-Stimulating Factor Leukocytes Mononuclear Animals Cytokines Humans RNA Messenger Naphthyridines Cyclophosphamide Cells Cultured Granulocytes |
| Zdroj: | Blood. 90(2) |
| ISSN: | 0006-4971 |
| Popis: | We have identified a small molecular weight compound, SCH 14988, which specifically stimulates in vitro granulocyte-colony stimulating factor (G-CSF) production from activated human peripheral blood mononuclear cells and monocytes but not other cytokines or CSFs with hematoregulatory activity. In vivo administration of SCH 14988 to mice rendered neutropenic by cyclophosphamide treatment resulted in the accelerated recovery of the peripheral neutrophil compartment. This activity correlated with increased in vivo G-CSF levels and stimulation of marrow granulopoiesis, and was comparable to that of exogenously administered recombinant human G-CSF. No alterations to other leukocyte populations in peripheral blood, spleen, or the peritoneal cavity were observed. These findings suggest that SCH 14988 may be clinically useful to enhance neutrophil granulopoiesis, as well as to study the mechanisms involved in G-CSF gene regulation. |
| Databáze: | OpenAIRE |
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