| Autor: |
F J, Symons, J, Tapp, A, Wulfsberg, K A, Sutton, W L, Heeth, J W, Bodfish |
| Rok vydání: |
2001 |
| Předmět: |
|
| Zdroj: |
Experimental and clinical psychopharmacology. 9(3) |
| ISSN: |
1064-1297 |
| Popis: |
Accumulated evidence shows that biology and the environment can mediate self-injurious behavior (SIB) in persons with mental retardation. Whether pharmacological treatment alters the environmental mediation of self-injury is unclear. Opioid antagonist effects on sequential dependencies for self-injury were studied in the context of experimental single-subject double-blind placebo-controlled designs. Direct observational data were collected for 4 adult subjects in real time on daily rate of SIB and staff interactions. Clinically significant reductions (i.e.,or = 33%) in SIB rate were observed for 3 of the 4 subjects. For all subjects, the magnitude of the sequential dependency between staff behavior and self-injury was significantly greater during treatment with naltrexone than during treatment with a placebo. Results are discussed in relation to behavioral mechanisms of action regulating medication effects for self-injury. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
