| Autor: |
Chao-Ling, Tang, Ning, Ma, Wan-Ying, Sun, Wei, Wang, Li-Peng, Zhu, Rui-Qi, Wang, Jie-Yan, Liu, Xiao-Po, Zhang |
| Rok vydání: |
2022 |
| Zdroj: |
Evidence-based complementary and alternative medicine : eCAM. 2022 |
| ISSN: |
1741-427X |
| Popis: |
Acetaminophen-related hepatic injury (ARHI) is a kind of acute hepatic injury caused by overdosing acetaminophen, which is mainly related to toxic metabolite production, oxidative stress, and mitochondrial dysfunction. The extract ofHere, the authors applied the approach based on serum metabonomics combined with network pharmacology to study the protection of PSM on ARHI rats.10 serum potential biomarkers were found to be closely related to ARHI by metabonomics, while 3 compounds (L-ascorbyl 2,6-dipalmitate, squalene, and tributyl O-acetylcitrate) and 3 targets (NOS2, MAOB, and PDE3A) were found that might be the potential active components and active site of PSM on treating ARHI by network pharmacology analysis. Furthermore, molecular biology strategy was performed to validate whether iNOS/NF-This study indicated that PSM could ameliorate ARHI by iNOS/NF |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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