RNAi Technique in Stem Cell Research: Current Status and Future Perspectives

Autor:	Gang-Ming, Zou
Rok vydání:	2017
Předmět:	RNAi Therapeutics Gene Expression Regulation Stem Cells Genetic Vectors Neoplastic Stem Cells Animals Humans RNA Interference Gene Silencing RNA Small Interfering Hematopoietic Stem Cells Stem Cell Research Embryonic Stem Cells
Zdroj:	Methods in molecular biology (Clifton, N.J.). 1622
ISSN:	1940-6029
Popis:	RNAi is a mechanism displayed by most eukaryotic cells to rid themselves of foreign double-strand RNA molecules. In the 18 years since the initial report, RNAi has now been demonstrated to function in mammalian cells to alter gene expression and has been used as a means for genetic discovery as well as a possible strategy for genetic correction and genetic therapy in cancer and other disease. The aim of this review is to provide a general overview of how RNAi suppresses gene expression and to examine some published RNAi approaches that have resulted in changes in stem cell function and suggest the possible clinical relevance of this work in cancer therapy through targeting cancer stem cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::8d8d36afda17b772b8ea58dde3dd7dc7 https://pubmed.ncbi.nlm.nih.gov/28674797 Zobrazit plný text záznamu