| Autor: |
Sanne, Huijberts, Liqin, Wang, Rodrigo Leite, de Oliveira, Hilde, Rosing, Bastiaan, Nuijen, Jos, Beijnen, Rene, Bernards, Jan, Schellens, Sofie, Wilgenhof |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Future oncology (London, England). 16(11) |
| ISSN: |
1744-8301 |
| Popis: |
The clinical benefit of treatment with BRAF- and MEK-inhibitors in melanoma is limited due to resistance associated with emerging secondary mutations. Preclinical and clinical studies have shown that short-term treatment with the HDAC inhibitor vorinostat can eliminate cells harboring these secondary mutations causing resistance. This proof of concept study is to determine the efficacy of sequential treatment with vorinostat and BRAFi/MEKi in resistant |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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