[The 3-phase reaction of cells of an MDCK culture to long-term exposure to antiviral chemical preparations]

Autor: V I, Votiakov, I R, Erokhina, T V, Amvros'eva
Rok vydání: 1989
Předmět:
Zdroj: Biulleten' eksperimental'noi biologii i meditsiny. 107(5)
ISSN: 0365-9615
Popis: A study was made of the effect of antiviral drugs remantadine and deitephorine on dynamics in the changes in structure-function parameters, mitotic activity, protein and nucleic acid synthesis in the Madin-Darby canine kidney cell culture. The application of methodical complex and regression analysis methods, the approximation of experimental data with analytical functions showed general regularity in the monolayer cell population response to the effect of drugs. In the response of cell populations three phases are distinguished: the first phase--transient inhibition; the second phase--relative compensation; the third phase--pathological cell destructive process.
Databáze: OpenAIRE