| Autor: |
Mountasser M, Al-Mouqdad, Dima Z, Jamjoom, Ayman T, Abdalgader, Waleed S, Ameen, Thanaa M, Khalil, Yasmeen S, Asfour, Maha R, Al-Anazi, Suzan S, Asfour |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Pediatric nephrology (Berlin, Germany). 37(12) |
| ISSN: |
1432-198X |
| Popis: |
This study aimed to investigate the relationship between acute kidney injury (AKI) in the first 2 weeks of life and brain injury on term-equivalent age magnetic resonance imaging in very preterm infants.We included 116 infants with a birth weight of 1500 g who were born at the King Saud Medical City at ≤ 32 gestational weeks. They were admitted to the neonatal intensive care unit and underwent term-equivalent age and pre-discharge brain magnetic resonance imaging. A negative binomial with generalized linear models and a robust variance estimator (Huber-White) was applied for univariate relative risk analysis. The Kidokoro score was then used to determine the effect of AKI on brain morphology and growth at term-equivalent age.Sixty-eight (64.2%) infants had developed an AKI in the first 2 weeks of life. AKI was significantly associated with cerebellum signal abnormalities, cerebellar volume reduction, and a high total cerebellum score (P = 0.04, P 0.001, P 0.001, respectively).AKI in the first 2 weeks of life is associated with brain insult, especially in the cerebellum. More well-designed studies are required to investigate the association and impact of AKI on the central nervous system. A higher resolution version of the Graphical abstract is available as Supplementary information. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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