Determination of mirtazapine and its demethyl metabolite in plasma by high-performance liquid chromatography with ultraviolet detection. Application to management of acute intoxication

Autor:	T, Romiguieres, F, Pehourcq, M, Matoga, B, Begaud, C, Jarry
Rok vydání:	2002
Předmět:	Reproducibility of Results Mirtazapine Spectrophotometry Ultraviolet Mianserin Antidepressive Agents Tricyclic Sensitivity and Specificity Chromatography High Pressure Liquid
Zdroj:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 775(2)
ISSN:	1570-0232
Popis:	Mirtazapine is a new centrally acting noradrenergic and specific serotonin antidepressant, with an active demethyl metabolite. For toxicological purposes, a specific and accurate RP-HPLC assay was developed for the simultaneous plasma determination of these compounds. A linear response was observed over the concentration range 50-500 ng/ml. A good accuracy (bias10%) was achieved for all quality controls, with intra-day and inter-day variation coefficients less than 8.3%. The lower limit of quantification was 20 ng/ml, without interferences with endogenous or exogenous components. This rapid method (run time12 min) was used to manage three intoxications involving mirtazapine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::8d610e6817256568c35c4580b9d6bbcb https://pubmed.ncbi.nlm.nih.gov/12113982 Zobrazit plný text záznamu Full Text from ScienceDirect