| Autor: |
Seki, Mitsuru, Powers, Jeffery C., Maruyama, Sonomi, Zuriaga, Maria A., Wu, Chia-Ling, Kurishima, Clara, Kim, Lydia, Johnson, Jesse, Poidomani, Anthony, Wang, Tao, Muñoz, Eric, Rajan, Sudarsan, Park, Joon Y., Walsh, Kenneth, Recchia, Fabio A. |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Popis: |
FSTL1 (follistatin-like protein 1) is an emerging cardiokine/myokine that is upregulated in heart failure (HF) and is found to be cardioprotective in animal models of cardiac injury. We tested the hypothesis that circulating FSTL1 can affect cardiac function and metabolism under baseline physiological conditions and in HF.FSTL1 was acutely (10 minutes) or chronically (2 weeks) infused to attain clinically relevant blood levels in conscious dogs with cardiac tachypacing-induced HF. Dogs with no cardiac pacing and FSTL1 infusion served as control.These findings support a novel function for FSTL1 and provide the first direct evidence that a circulating cardiokine/myokine can alter myocardial and systemic energy substrate metabolism, in vivo. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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