An investigation of the spectrum of common and rare inherited coagulation disorders in north-eastern Iran
| Autor: | Hassan, Mansouritorghabeh, Lida, Manavifar, Abdollah, Banihashem, Alireza, Modaresi, Abbas, Shirdel, Masoud, Shahroudian, Ghazaleh, Shoja-E-Razavi, Hamid, Pousti, Habibollah, Esmaily |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Aged 80 and over Male Adolescent Data Collection Infant Original Articles Iran Middle Aged Hemophilia A Hemorrhagic Disorders Hemophilia B Blood Coagulation Factors Young Adult von Willebrand Diseases Blood Coagulation Disorders Inherited Child Preschool Humans Female Blood Platelet Disorders Child Aged |
| Zdroj: | Blood transfusion = Trasfusione del sangue. 11(2) |
| ISSN: | 2385-2070 |
| Popis: | Health care officials and legislators need accurate data on prevalence and numbers of individuals with bleeding disorders in order to plan and allot their budgets; the manufacturers of coagulation factors also need these data to estimate the amount of factors required to prevent scarcity of these products.We surveyed the prevalence of haemophilia A, haemophilia B, von Willebrand's disease and rare bleeding disorders in North-Eastern Iran. The survey was done in the period from September 2009 to March 2011. Information was collected from the medical records in three major hospitals and a haemophilia centre; the patients' updated data were obtained by telephone.Overall in the current survey 552 patients with inherited coagulation disorders were identified and their medical records obtained. Of these, 429 (77.5%) had common bleeding disorders (haemophilia A, haemophilia B, von Willebrand's disease), 85 (15.6%) had rare bleeding disorders (deficiency of coagulation factors V, VII, X, XIII, I, XI, combined factor V and VIII deficiency) and 38 (6.9%) had platelet disorders.The commonest bleeding disorders were haemophilia A (n=287, 51.9%), haemophilia B (n=92, 16.6%), von Willebrand's disease (n=50, 9%), factor V deficiency (n=21, 3.8%), factor VII deficiency (n=19, 3.4%), factor X deficiency (n=2, 0.36%), combined factor V and VIII deficiency (n=28, 5.8%), factor XIII deficiency (n=11, 1.99%), factor XI deficiency (n=2, 0.4%), afibrinogenaemia (n=2, 0.36%) and platelet disorders (n=38, 6.9%).There is notable population of individuals with bleeding disorders in North-Eastern Iran. |
| Databáze: | OpenAIRE |
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