| Autor: |
V E, Pogorelyĭ, M D, Gaevyĭ, A V, Arl't, E R, Davidov, V V, Gatsura |
| Rok vydání: |
1996 |
| Předmět: |
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| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia. 59(5) |
| ISSN: |
0869-2092 |
| Popis: |
The effect of animal cytochrome C (Ca), biotechnological cytochrome (Cb) and its hemtetradecapeptide (HTDP) on cerebral blood flow autoregulation during rapid decrease of systemic arterial pressure (SAP) was studied in acute experiments on rats. Cytochrome C preparations caused no effect on the autoregulatory responses of the cerebral vessels in animals with normal cerebral circulation. Injection of 5 mg/kg Ca and Cb and 0.8 mg/kg HTDP promoted restoration of the phenomenon of cerebral blood flow autoregulation in ischemic brain damage in change of SAP from 120 to 60 mm Hg. Prophylactic injection of 20 mg/kg Ca and Cb and 3.3 mg/kg HTDP prevented cerebral blood flow autoregulation disturbance caused by transitory brain ischemia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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