| Autor: |
P, Kiepiela, H M, Coovadia, W E, Loening, P, Coward, S S, Abdool Karim |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 79(3) |
| ISSN: |
0256-9574 |
| Popis: |
In order to investigate the feasibility of measles vaccination before the age of 9 months the duration of passive immunity against measles was estimated by conducting a longitudinal study of measles antibody levels in 20 black neonates delivered at term. Measles serum antibody (IgG) was measured by enzyme-linked immunosorbent assay in the mother at childbirth and on consecutive samples taken from the infants from birth until 9 months of age. Protective measles antibody level was defined as greater than 200 mIU. Unprotective levels were found in 88% (95% confidence interval (CI) 81-99%) of 6-month-old infants, while at 9 months all were susceptible. The mean antibody level was 192 mIU (CI 104-348%) at 4 months; 34 mIU (CI 15-73%) at 6 months and 13 mIU (CI 6-24%) at 9 months of age. Our data support the recent World Health Organisation recommendation to immunise children in developing countries at 6 months with the 'high titre' Edmonston-Zagreb measles vaccine, since most infants in our study had lost passive immunity against measles by this age. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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