[Determination by thermometric titrimetry of the thermodynamic parameters of water/n-octanol transfer of several non-steroidal anti-inflammatory drugs]

Autor:	G, Burgot, J L, Burgot
Jazyk:	francouzština
Rok vydání:	1995
Předmět:	Octanols Thermometers Anti-Inflammatory Agents Non-Steroidal Titrimetry Thermodynamics Water
Zdroj:	Annales pharmaceutiques francaises. 53(1)
ISSN:	0003-4509
Popis:	The calorimetric determination by thermometric titrimetry of the water/n-octanol transfer enthalpies of some non steroidic anti-inflammatory compounds is described. By combining the values obtained with that of the free enthalpies of transfer issuing from the values of corresponding log P, it is possible to determinate the transfer entropies of the solutes. The whole results of the show that almost the transfers are both enthalpy and entropy driven. They demonstrate the occurrence of three different mechanisms of transfer.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::8d295b9b4f3be2ca6952ff24b3ddc140 https://pubmed.ncbi.nlm.nih.gov/7741421 Zobrazit plný text záznamu