| Autor: |
P, Altmayer, E, Groterath, P W, Lücker, D, Mayer, H, von Mayersbach, W, Rindt, K, Wetzelsberger |
| Jazyk: |
němčina |
| Rok vydání: |
1979 |
| Předmět: |
|
| Zdroj: |
Arzneimittel-Forschung. 29(9) |
| ISSN: |
0004-4172 |
| Popis: |
To 4 male and 2 female subjects hexobarbital was applied orally at different times of the day: 2, 10, 18 h. Serum concentrations of hexobarbital were determined by HPLC procedure and the resulting pharmacokinetic parameters in a rotating iterative program. Application at 18 h resulted in a shorter invasion time, a higher maximum concentration and a delayed elimination; in addition, the AUC was elevated in relation to application at 2 or 10 h. In the 2 female subjects a different pattern was observed. The results lead to the assumption that application of hexobarbital is more effective in the evening than in the morning. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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