| Autor: |
K, Kitada, Y, Hashiguchi, T, Fukuda, H, Yoshida, T, Ichimura, Y, Matsumoto, T, Yasui, T, Sumi, O, Ishiko |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
European journal of gynaecological oncology. 33(3) |
| ISSN: |
0392-2936 |
| Popis: |
Chemotherapy-related hypersensitivity reaction seems to be problematic in the safe management of chemotherapy. In this study we investigated chemotherapy-related hypersensitivity reaction in patients with gynecologic malignancy.Between January 2009 and December 2010, we examined hypersensitivity reaction (or = grade2) using the Common Terminology Criteria for Adverse Events (CTCAE) v.4.0. We analyzed the incidence, clinical features, management, and outcome.We administered over 1,057 infusions (24 regimens) to 205 patients. We found a total of four hypersensitivity reactions (or = grade 2) cases (carboplatin: 2; nedaplatin: 1; docetaxel: 1). Signs and symptoms were varied. In two cases, the same regimen was rechallenged by using anti-allergic drugs. The docetaxel case was successful. The carboplatin case was not successful.Chemotherapy-related hypersensitivity reaction (or = grade2) does not occur frequently. In the case of platinum, especially, carboplatin, re-administering after hypersensitivity reaction should be done carefully though platinum is a key drug in patients with gynecologic malignancies. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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