| Autor: |
E R, Chernykh, M A, Tikhonova, A A, Ostanin, E Ia, Shevela, I A, Blazhievich, G Z, Shubinskiĭ |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
Vestnik Akademii meditsinskikh nauk SSSR. (12) |
| ISSN: |
0002-3027 |
| Popis: |
The data presented indicate that B cells from patients with chronic lymphocytic leukemia (CLL) may produce suppressive factors capable of inhibiting T and B cell proliferation and Ig secretion. Two factors with the molecular weight 65-75 KDa (SBF1) and 15-25 KDa (SBF2) have been characterized. SBFs are primarily produced by B cells with a low flow density. There is a reverse dependence between the capacity of leukemic B cells for spontaneous Ig secretion and their ability for the production of suppressive factors. The autocrine and paracrine pathways of B cell regulation in the pathogenesis of chronic lymphocytic leukemia are discussed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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