| Autor: |
K, Gladstien, L J, Shapiro, M A, Spence |
| Rok vydání: |
1979 |
| Předmět: |
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| Zdroj: |
American journal of human genetics. 31(6) |
| ISSN: |
0002-9297 |
| Popis: |
We derive the conditional probabilities for estimating the sex ratio in families ascertained through affected males for the study of X-linked recessive diseases. These conditional probabilities correct for the fact that the probability that a family will be ascertained increases with the number of males in the family. Data from four published studies for X-linked ichthyosis vulgaris are analyzed, three having an excess of males and one having a highly statistically significant excess of males. It is not known if this difference in the two samples represents a biological difference between the two populations or an unrecognized ascertainment bias. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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