| Autor: |
R P, Shiu, P H, Watson, D, Dubik |
| Rok vydání: |
1993 |
| Předmět: |
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| Zdroj: |
Clinical chemistry. 39(2) |
| ISSN: |
0009-9147 |
| Popis: |
We demonstrate that c-myc gene expression is essential for growth of breast cancer cells. It also plays an important role in the progression of human breast cancer. c-myc gene amplification may be important for cancer cell invasion, but perhaps not essential for nodal metastasis. We also provide compelling evidence that the c-myc oncogene is an estrogen target gene in hormone-responsive breast cancer. Hormonal progression of breast cancer could be brought about by the enhanced expression of the c-myc gene, with gene amplification and enhanced c-myc mRNA stability being two major mechanisms involved. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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