A reversed-phase high-performance liquid chromatography assay procedure for progabide and its related metabolic derivatives

Autor:	N F, Farraj, S S, Davis, G D, Parr, H N, Stevens
Rok vydání:	1987
Předmět:	Solutions Calibration Chromatography High Pressure Liquid gamma-Aminobutyric Acid
Zdroj:	Pharmaceutical research. 4(1)
ISSN:	0724-8741
Popis:	A reversed-phase high-performance liquid chromatography (HPLC) assay procedure for Progabide, its active acid metabolite (PGA), and its hydrolytic degradation product (SL79.182) has been developed. This highly specific technique has allowed the simultaneous determination of these drugs in aqueous samples, and when coupled with a single and easy extraction step, spiked plasma samples could also be analyzed. The method had a sensitivity of about 30, 45, and 100 ng/ml for Progabide, SL79.182, and PGA, respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::8c6136f0f3c3bc31e6cedf4abf30ca43 https://pubmed.ncbi.nlm.nih.gov/3508525 Zobrazit plný text záznamu Full text from SpringerLink