| Autor: |
Theepa, Thayalakulasingam, Rehan, Mohammed, Shibu, Varughese, Arthur, Zieske, David L, Smith, Lee S, Engel, Brian, Boulmay, Fred A, Lopez |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society. 163(5) |
| ISSN: |
0024-6921 |
| Popis: |
Budd Chiari syndrome is a rare disorder resulting from hepatic venous outflow tract obstruction anywhere from the small hepatic veins to the suprahepatic inferior vena cava. This patient has a hypercoagulable state secondary to heterozygous mutation of factor V and the JAK2 mutation and is being anticoagulated. We hypothesize that the low protein C and low antithrombin III levels seen in this patient resulted from decreased synthetic function of the liver and were not indicative of actual deficiencies. Indeed, reports of coexisting protein C and antithrombin III deficiencies are not existent in the literature and likely are not compatible with life. All patients with BCS warrant a hypercoagulable work up and JAK2 mutation is increasingly recognized as a contributing factor, even in those patients without obvious signs of polycythemia vera. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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