| Autor: |
L C, Pontes De Carvalho, R, Badaró, E M, Carvalho, J, Lannes-Vieira, L, Vinhaes, G, Orge, M C, Marsochi, B, Galvão-Castro |
| Rok vydání: |
1986 |
| Předmět: |
|
| Zdroj: |
Clinical and experimental immunology. 64(3) |
| ISSN: |
0009-9104 |
| Popis: |
IgG molecules were found associated with erythrocyte membranes in all patients with American visceral leishmaniasis. They were detected by two different immunoradiometric assays and by one enzyme-linked immunosorbent assay. Although autoimmune phenomena seem to be constant features of American visceral leishmaniasis, the erythrocyte-bound IgG are not erythrocyte-specific autoantibodies. Moreover, anti-Leishmania activity was found associated with the erythrocyte-bound IgG, indicating that the IgG may be a component of Leishmania antigens-anti-Leishmania immune complexes. No associations were found between the amounts of erythrocyte-bound IgG and the degree of anaemia or between spleen dimensions and the degree of anaemia. These findings suggest that the pathogenesis of anaemia in American visceral leishmaniasis is multifactorial. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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