In line with our ancestors: Oct-4 and the mammalian germ
| Autor: | M, Pesce, M K, Gross, H R, Schöler |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Gene Expression Regulation Developmental Cell Differentiation Cell Line DNA-Binding Proteins Embryonic and Fetal Development Meiosis Mice Drosophila melanogaster Germ Cells Species Specificity Multigene Family Vertebrates Animals Humans Cell Lineage Female Octamer Transcription Factor-3 Transcription Factors |
| Zdroj: | BioEssays : news and reviews in molecular, cellular and developmental biology. 20(9) |
| ISSN: | 0265-9247 |
| Popis: | The transcription factor Oct-4 is expressed specifically in the totipotent germline cycle of mice. Cells that lose Oct-4 differentiate along different paths to form embryonic and extraembryonic somatic tissue. Oct-4 may maintain the potency of stem and germline cells by preventing all other differentiation pathways. Oct-4 may also regulate the molecular differentiation of cells in the germ lineage as it progresses from the fertilized egg, through cleavage stage/morula blastomeres, blastocyst, inner cell mass, epiblast, germ cells, and gametes. The factors that regulate, and are regulated by, Oct-4 are reviewed with respect to the phenomena of cell potency and germ/soma segregation and differentiation. |
| Databáze: | OpenAIRE |
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