| Autor: |
Masaki, Hirukawa, Shingo, Katayama, Tatsuya, Sato, Kota, Inoue, Kosuke, Niwa, Naoya, Ito, Tetsuya, Hattori, Takashi, Hosoi, Hironori, Unno, Yoshiaki, Suzuki, Masahiro, Hasegawa, Keiichi, Miyamoto, Takashi, Horiuchi |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Artificial organs. 42(7) |
| ISSN: |
1525-1594 |
| Popis: |
Ligament reconstruction using a tissue-engineered artificial ligament (TEAL) requires regeneration of the ligament-bone junction such that fixation devices such as screws and end buttons do not have to be used. The objective of this study was to develop a TEAL consisting of elastin-coated polydioxanone (PDS) sutures covered with elastin and collagen fibers preseeded with ligament cells. In a pilot study, a ring-type PDS suture with a 2.5 mm (width) bone insertion was constructed with/without elastin coating (Ela-coat and Non-coat) and implanted into two bone tunnels, diameter 2.4 mm, in the rabbit tibia (6 cases each) to access the effect of elastin on the bond strength. PDS specimens taken together with the tibia at 6 weeks after implantation indicated growth of bone-like hard tissues around bone tunnels accompanied with narrowing of the tunnels in the Ela-coat group and not in the Non-coat group. The drawout load of the Ela-coat group was significantly higher (28.0 ± 15.1 N, n = 4) than that of the Non-coat group (7.6 ± 4.6 N, n = 5). These data can improve the mechanical bulk property of TEAL through extracellular matrix formation. To achieve this TEAL model, 4.5 × 10 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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